Author

Siew Chin Chan

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Open access Sep 2026

miR-196a reduces mutant Huntingtin aggregates by Rad23b-mediated degradation in Huntington’s disease

Huntington’s disease (HD) is a neurodegenerative disorder caused by abnormal expansions of poly-glutamine repeats in the mutant Huntingtin (mHTT). The expanded proteins form pathological aggregates to disrupt neuronal functions during disease progression, suggesting the clearance of the aggregates is considered as a po...

Chih-Wei Tung, Siew Chin Chan, Yi-Ching Chen et al. · Journal of Biomedical Scienc... · 0 citations

Open access Aug 2026

Wild-type C9orf72 drives proteasomal dysfunction and mutant aggregates via a Stat1-Isg15 axis in Huntington's disease.

A previously unrecognized modulatory role of wt-C9orf72 in regulating mHTT aggregation in experimental HD models is identified and a novel wt-C9orf72-Stat1-Isg15 axis is identified, providing new insights into wt-C9orf72-associated protein homeostasis.

Siew Chin Chan, Chih-Wei Tung, Chih-Yi Chang et al. · Neurotherapeutics · 0 citations