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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Sigourney Karijodikoro

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Open access Aug 2026

Hyphenated Mass Spectrometry-Based Strategies for Characterizing Oligomers of α‑Synuclein in Parkinson’s Disease

The pathological aggregation of α-synuclein (α-syn), an intrinsically disordered protein that regulates synaptic vesicle trafficking in the brain, is a defining molecular feature in Parkinson’s disease (PD). Early oligomeric assemblies are widely considered the most neurotoxic species, yet their structural features rem...

Raya Sadighi, Andrea Istrati, Sigourney Karijodikoro et al. · 1 citation

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