This work proposes a ten-metric benchmarking framework and discusses the opportunities and remaining challenges for translational readiness in tauopathy modeling, and identifies three challenges for their translational readiness, maturity, disease-relevant cellular complexity, and pathological accuracy.
A. Guruacharya, Thomas Hartung, Roberta Souza dos Reis et al.· Stem Cell Reports· 0 citations
A deeper understanding of these processes may contribute to the identification of innovative interventions for age-related disorders, such as therapies targeting specific components of the senescence-associated secretory phenotype or selectively modulating senescent cell burden.
Francesca Cristiana Piritore, Michele Braggio, Arianna Minoia et al.· Cellular and Molecular Life...· 1 citation
Data show that LRRK2-G2019S impairs astrocyte specification and predisposes to a senescent phenotype, which contributes to the acquisition of a senescent-like phenotype in Parkinson’s disease patients.
Lisa M. Smits, S. Magni, K. Grzyb et al.· npj Parkinson's Disease· 0 citations
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