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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Simon Gross

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Open access Aug 2026

Synthesis and Pharmacological Characterization of Novel Tetrahydropyridine-Based Muscarinic M5 Receptor Antagonists to Investigate the Difference in the SARs of Muscarinic Receptor Subtypes Utilizing Induced Fit Docking Studies

Many studies and experiments suggest the muscarinic M5 receptor (M5R) as a potential target for the clinical treatment of drug abuse, schizophrenia, or Alzheimer’s disease. In the present study, a library containing 39 novel hM5R antagonists based on an arecaidine (tetrahydropyridine) core was synthesized, pharmacolo...

Simon Gross, P. Koch, A. Strasser · 0 citations

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