Highly‐Sensitive Liquid Chromatography Triple Quadrupole Mass Spectrometry Method for the Ultra‐Trace Quantification of N‐Nitrosamine Impurity in Opipramol Drug Substance and Tablet Formulations
Regulatory bodies require strict control of N‐nitrosamine drug substance‐related impurities due to their possible carcinogenic risk. In this work, a quick and highly sensitive liquid chromatography coupled triple quadrupole mass spectrometry method was established for the trace‐level quantification of the nitrosamine...