Open access
Aug 2026
Novel Wnt potentiators induce iPSC-derived cardiomyocyte proliferation and increase embryonic zebrafish heart size.
Canonical Wnt/β-catenin pathway activation can promote cardiomyocyte (CM) cell cycle activity, but translation is limited by off-target and functional liabilities associated with global pathway activation. We identified two small molecules, LRN9 and DF6, which potentiate Wnt/β-catenin signaling through a non-GSK3β mech...
Daniela T Asenjo, Lynn A. C. Devilée, Aaron H. Wasserman et al.
· Journal of Molecular and Cel... · 0 citations