Author

Siyu Chen

2 papers indexed here

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Aug 2026

Discovery of Polycyclic Polyprenylated Acylphloroglucinols from Hypericum androsaemum as Dual-Mechanism Inhibitors of Mycobacterium tuberculosis GlmU Acetyltransferase.

(±)-Hypericandrone A (HCA, 1), an unprecedented pair of enantiomeric polycyclic polyprenylated acylphloroglucinols (PPAPs), and its biosynthetic congener hypericandrone B (HCB, 2) were isolated from the fruits of Hypericum androsaemum. Compound 1 features a unique 2-cyclopentane-bicyclo[3.3.0]octane scaffold, while 2 p...

Jiang-Chun Wei, Xing-Piao Jin, Xiang-Wang Zhao et al. · Organic Letters · 1 citation

Aug 2026

10,11-Dehydrocurvularin suppresses non-small cell lung cancer by targeting PAICS and inducing apoptosis.

Non-small cell lung cancer (NSCLC) remains one of the leading causes of cancer-related mortality worldwide, highlighting the urgent need for effective therapeutic agents. Natural products represent an important source of novel anticancer compounds. In this study, we investigated the anti-NSCLC activity of 10,11-dehydro...

Yue Wang, Siyu Chen, Ping Huang et al. · Bioorganic chemistry (Print) · 0 citations