Open access
Jul 2026
TMEM135 deficiency remodels hepatic lipid homeostasis and protein malonylation through a DHA-sensitive lipogenic program buffered by peroxisomal metabolism
These findings identify TMEM135 as a central regulator of hepatic lipid metabolism and uncover a coordinated mechanism linking lipid availability, lipogenesis, and post-translational metabolic regulation.
Ryo Hagimori, Michael Landowski, Siyu Song et al.
· bioRxiv · 0 citations