Recursive splicing (RS) is a process in which an intron is removed from a nascent RNA molecule in two or more splicing events rather than one. We introduce a novel approach for detecting recursive splice sites (RSSs), the intronic loci at which RS events occur, based on alignment of total RNA-seq data to short, customi...
David J. Bass, Steven L. Salzberg· bioRxiv· 0 citations
Kmask, an entropy-based masking tool implemented for use either standalone or as part of Kraken database construction, which replaces low-entropy regions with Ns, is presented, demonstrating that it is an effective method for masking low-complexity sequences in large microbial databases, thus improving the accuracy of...
Yu-Chen Ge, Edward Z. Li, Harun Mustafa et al.· bioRxiv· 0 citations
A telomere-to-telomere genome benchmark with near-perfect accuracy across 99.4% of the diploid HG002 genome is presented, expanding the reach of genomic medicine to the entire genome and enabling a new era of personalized genomics.
Nancy F. Hansen, Nathan Dwarshuis, Hyun Joo Ji et al.· Cell· 8 citations
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