Sneh N. Patel

Design, synthesis, and biological evaluation of fluorinated α-cyanoacrylohydrazide derivatives as promising EGFR-targeted anticancer agents: Structure–activity relationship and integrated computational investigations using molecular docking, molecular dynamics simulation, MM-GBSA, DFT, and in silico

A novel series of fluorinated α-cyanoacrylohydrazide derivatives 5(a–p) was systematically designed, synthesized, and characterized by FT-IR, 1 H NMR, 13 C NMR, MS, and elemental analysis as potential EGFR-targeted anticancer agents. In vitro antiproliferative evaluation against five human cancer cell lines...