Snehal M Gaikwad

Stability of c-Myc protein differentiates Ras oncogene addiction and MAPK pathway dependency in Ras-mutant multiple myeloma

It is demonstrated that c-Myc protein stability differentiates the response of Ras-mutant MM cells to Ras and MEK inhibition, and suggested that direct targeting of the Ras oncoprotein, rather than its downstream MAPK pathway, may present a more effective strategy.