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Author

Snehal Nirgude

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2 papers indexed here

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Sep 2026

Abstract C017: Patient-Derived iPSC Liver Organoids Model Embryonal Hepatic Reprogramming and Collagen IV-Integrin Signaling in BWS-Associated Hepatoblastoma

Beckwith-Wiedemann syndrome (BWS) is a cancer predisposition disorder caused by epigenetic alterations at chromosome 11p15, which confers increased risk of hepatoblastoma in early childhood. The mechanisms linking 11p15 dysregulation to tumor initiation remain unclear. Building on our previously published single-...

Snehal Nirgude, Madison Newsome, Elisia D. Tichy et al. · 0 citations
Open access Sep 2026

Myogenic dysregulation underlies human tongue overgrowth in Beckwith-Wiedemann syndrome

Summary Macroglossia is a clinically significant feature of Beckwith-Wiedemann syndrome (BWS), but the cellular basis of tongue overgrowth remains poorly defined. Using pediatric tongue specimens from molecularly defined BWS subtypes and age-matched nonBWS controls, we show that BWS macroglossia is characterized by ske...

Elisia D. Tichy, Anna T. Nguyen, Mariah Byrne et al. · 0 citations

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