Sofia Moco

A human iPSC-derived kidney–liver organ-on-a-chip platform for modeling inter-organ crosstalk

The liver and kidneys are essential for drug metabolism and clearance and are highly sensitive to toxicity. Most in vitro models assess these organs in isolation, limiting the study of inter-organ interactions. Here, an induced pluripotent stem cell (iPSC)-derived kidney–liver organ-on-a-chip model was developed that c...