Sohrab Salehi

An information-theoretic framework for inferring T cell dynamics from single-cell RNA and T cell receptor sequencing.

Single-cell T cell receptor (TCR) repertoire sequencing enables simultaneous profiling of gene expression and TCR sequences, providing a coregistered measure of T cell phenotypic diversity and clonal dynamics. However, principled probabilistic frameworks for joint modeling of clonotype and phenotype have remained limit...