Author

Sohyoung Kim

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Open access Sep 2026

SMYD3 protein degraders in HPV-negative head and neck squamous cell carcinoma

Despite the advent of immunotherapy in the treatment of human-papilloma-virus (HPV)-negative head and neck squamous cell carcinoma, the overall prognosis still remains dismal. Novel therapeutic approaches are thus urgently needed. We recently reported that SET and MYND containing 3 (SMYD3), a protein methyltransferase...

Jawad Akhtar, Sai Reddy Doda, William J. Moore et al. · bioRxiv · 0 citations

Open access Sep 2026

Oncogenic and immunomodulatory functions of SUV420H1 in HPV-negative head and neck squamous cell carcinoma

This work provides rationale for the depletion/degradation of SUV420H1 as a novel therapeutic strategy to hinder proliferation and invasion, and to impart sensitization to anti-PD-1 immunotherapy for patients with HPV-negative HNSCC tumors with SUV420H1 gain/amplification.

Arfa Moshiri, Marie Luff, Sohyoung Kim et al. · Cell Death & Disease · 0 citations

Jul 2026

Immunomodulatory Tr1 CD4 T cells induced by engineered V1-deleted HIV vaccine candidate decrease the risk of SIV acquisition in macaques 2267572

Investigating how the vaccine shapes the CD4+ T cell immunity and how these responses cooperate in reducing the acquisition found that DV1 DNA/ALVAC/gp120 vaccine elicited envelope-specific immunomodulatory Tr1 CD4+ T cells, and that total Tr1 responses were associated with a reduced risk of viral acquisition.

Massimiliano Bissa, S. Fourati, Sohyoung Kim et al. · Journal of Immunology · 0 citations