Author

Sokol V. Todi

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Review Open access Sep 2026

Ubiquitin-Dependent Protein Quality Control in Polyglutamine Diseases.

Polyglutamine diseases comprise a family of nine age-dependent disorders caused by CAG triplet-repeat expansions that produce misfolded proteins with elongated glutamine tracts. Although these diseases share proteotoxic stress and engagement of protein quality control pathways as responses to their presence and disrupt...

Matthew V. Prifti, Kristin Richardson, Sokol V. Todi · Aging and Disease · 0 citations

Review Open access Sep 2026

Polyamines across neurodegenerative proteinopathies.

Polyamines (PAs) are evolutionarily conserved metabolites that connect protein quality control with lysosomal, mitochondrial, and redox homeostasis. Their metabolism is situated at a critical intersection of cell-sustaining and neurodegenerative pathways. Here, we synthesize evidence across Alzheimer's disease, Parkins...

Bedri Ranxhi, Peter A. LeWitt, Wei-Ling Tsou et al. · Neurobiology of Disease · 0 citations