Somaia T Mansour

Nano-enabled delivery of natural products and combinatorial chemotherapy for triple-negative breast cancers: mechanisms, synergy, and translational challenges

This review critically evaluates current methodologies for assessing drug synergism, including the Chou–Talalay, Bliss independence, and Loewe additivity models, and highlights the lack of standardized application across studies, as well as addressing key translational challenges.