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Nov 2026

Mitochondria-Localized Three-Color Fluorescent Sensor for Concurrent Tracking of Mitochondrial H2O2, Hypochlorite and Subcellular Viscosity during Oxidative Stress and Drug-Related Hepatic Damage

We report a naphthalimide derived mitochondrial targeting fluorescent probe MT for real time simultaneous visualization of mitochondrial hydrogen peroxide (H2O2), hypochlorite (ClO−), and subcellular microviscosity, three key biomarkers closely associated with oxidative stress mediated drug induced liver injury. Free...

Xu-Feng Hou, Zhen Yang, Jia-Hui Li et al. · 0 citations
Aug 2026

Dual-response mitochondria-targeted fluorescent probe for Hypochlorous acid and viscosity: Applications in liver injury diagnosis and environmental monitoring.

The TPTY-Q-HClO probe enables real-time visualization of HClO overproduction and microenvironmental viscosity elevation in drug-induced liver injury and nonalcoholic fatty liver disease models, establishing a direct correlation between HClO-mediated oxidative stress and liver damage.

Peng Hou, Qi Zhang, Jun-Qiang Liu et al. · 0 citations

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