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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Song-Cheng Yu

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Aug 2026

Orthogonal Cas13a/Cas12a cascade for one-pot amplification-free detection of miRNA-21.

MicroRNAs (miRNAs) are promising biomarkers for clinical diagnosis and disease monitoring. However, current CRISPR/Cas-based miRNA sensors generally require reverse transcription or nucleic acid amplification to improve sensitivity, which complicates the workflow and increases the risk of contamination, nonspecific amp...

Jing Yuan, Meng Shen, Li-Hua Ding et al. · 0 citations
Jul 2026

CRISPR/Cas12a-coupled organic electrochemical transistors for highly sensitive detection of methylated DNA.

A methylation-sensitive bioelectronic sensing platform that integrates AciI-assisted target discrimination, CRISPR/Cas12a-mediated trans-cleavage, and vertical organic electrochemical transistors (vOECTs) amplification for highly sensitive methylated DNA detection is reported.

Kun Xu, Si-Bo Wang, Kejie Zhang et al. · 0 citations
Jul 2026

Signal logic gate mediated by a controllable CRISPR/Cas12a system for simultaneous detection of DNA mutation and methylation.

A controllable CRISPR/Cas12a-based signal logic gate that enables simultaneous detection of KRAS G12C mutation and Septin9 promoter methylation in a single reaction and offers a simple and reliable platform for simultaneous genetic and epigenetic analysis in point-of-care cancer screening.

Zonghua Wen, Cong Wei, Meng Shen et al. · 0 citations

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