Open access
Dec 2025
DeepAden: an explainable machine learning method for predicting the substrate specificity of nonribosomal peptide synthetases
DeepAden achieves competitive performance compared with state-of-the-art tools on a benchmark dataset, and enabled the identification of two Streptomyces NRPS gene clusters through accurate A-domain substrates specificity predictions.
Jiaquan Huang, Liangjun Ge, Yaxin Wu et al.
· bioRxiv · 0 citations