Open access
Jul 2026
Humanized B-hIL4/hIL4RA/hTSLP/hTSLPR plus mice Model for Efficacy and Toxicity Evaluation 2302190
The IL-4 receptor (IL4RA) is a key mediator of the signaling pathways for both IL-4 and IL-13, which play pivotal roles in the pathophysiology of type 2 inflammatory diseases. Thymic stromal lymphopoietin (TSLP) is an alarmin cytokine derived from epithelial cells that has the capacity to initiate both type 2 and...
Yuan Tian, Biying Hong, Liya Yang et al.
· Journal of Immunology · 0 citations