Open access
Aug 2026
Nucleosomes and IDRs suppress promiscuous GCN4 binding on minichromosomes
Eukaryotic sequence-specific transcription factors (TFs) must find their cognate DNA targets hidden in genomic chromatin amid an excess of nonspecific sequences and degenerate motifs. Although static TF interactions with nucleosomal targets have been elucidated, how TFs efficiently search for cognate sites within nativ...
Ze-Lin Wei, Oluwakemi E. Abiodun, Y. Ling et al.
· Nature Structural & Molecula... · 0 citations