Open access
Jul 2026
Mechanistic study of chenodeoxycholic acid targeting pyruvate kinase to regulate hepatic lipid metabolism
In vitro and in vivo experiments demonstrated that CDCA notably ameliorated hepatic lipid deposition, and its underlying mechanism was revealed to be closely associated with the direct binding of CDCA to PK and subsequent enhancement of PK activity.
Xiao Zhang, Songling Tan, Xin-Hua Zhou
· Biomedical Reports · 0 citations