Catalpol extends lifespan through sod-3-mediated mitophagy in Caenorhabditis elegans.
Autophagy is an essential process that helps cells maintain balance by breaking down and reusing damaged organelles and abnormal proteins. The decline in its function is widely acknowledged as a significant contributor to aging. Catalpol (CAT), the main active ingredient in Rehmannia root, shows promise for treating ag...