Soon Young Shin

6-(2-Hydroxybenzoyl)pyrazolo[1,5-a]pyrimidine-3‑carbonitriles as novel reactive oxygen species-generating anticancer agents inducing ER stress and DNA damage in EGFR-mutant non-small cell lung cancer.

A series of twenty-one 6-(2-hydroxybenzoyl)pyrazolo[1,5-a]pyrimidine-3‑carbonitrile derivatives (HBPs), incorporating a pyrazolo[1,5-a]pyrimidine scaffold with a Michael acceptor moiety, were designed and synthesized as novel reactive oxygen species (ROS)-generating anticancer agents. Following structural characterizat...

Transcriptomic and network analyses identify epigenetic regulators of drug-tolerant persister (DTP) subsets in EGFR-mutant HCC827 non-small cell lung cancer.