Author

Soonsil Hyun

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Sep 2026

Tetracyclic pyrazinocarbazole derivatives as YAP-TEAD pathway inhibitors with activity in a melanoma lung colonization model.

Direct pharmacological disruption of the YAP-TEAD transcriptional complex is a promising strategy for Hippo pathway-driven cancers, but chemically tractable small-molecule chemotypes with in vivo activity remain limited. Here, we describe the optimization of a pirlindole-derived tetracyclic pyrazinocarbazole scaffold t...

Xiang Fei, Sanha Lee, Chaelin Lee et al. · Bioorganic chemistry (Print) · 0 citations

Open access Aug 2026

(S)‐Pyrrolo[1,2‐a]pyrazine‐3‐carboxamide Analogs as Dual Akt/JNK Modulators With Antiproliferative Effects in MDA‐MB‐468 Cells

Findings support the development of N2‐benzyl‐(S)‐1‐oxo‐1,2,3,4‐tetrahydropyrrolo[1,2‐a]pyrazine‐3‐carboxamide analogs, particularly compound B1, as selective therapeutic candidates for triple‐negative breast cancer.

Narges Hosseininasab, S. Kim, Y. Kwon et al. · ChemMedChem · 0 citations