Open access
Oct 2026
T-BET promotes inflammatory specialization without driving terminal maturation of iPSC-derived NK cells
Induced pluripotent stem cells (iPSCs) provide a scalable platform for off-the-shelf immune cell therapies; however, the mechanisms controlling maturation and functional specialization of iPSC-derived natural killer (iNK) cells are not fully understood. In this study, we combined single-cell transcriptomics, phenotyp...
C. Marsal, Muhammad Kashif, Sophia Borate et al.
· Frontiers in Pharmacology · 0 citations