Structure-Activity-Based Electrode-Fibril Interaction and Selective Electrochemical Disassembly of Fibrils via ROS-Mediated Structural Collapse.
The pathological aggregation of misfolded proteins into β-sheet-rich amyloid fibrils underlies a broad spectrum of debilitating diseases, yet strategies capable of effectively reversing these supramolecular assemblies remain an open challenge. Here, we demonstrate that a selective electrode-fibril interaction could be...