Halogen-Bonding-like Interactions Complement Hydrogen Bonding in a Human Flavin-Dependent Dehalogenase.
An accurate description of halogen bonding in biomolecules remains a challenge in modern biochemistry, as exemplified by the flavin-dependent human dehalogenase, iodotyrosine deiodinase. Analyses of the static crystal structure and kinetics data suggested that halogen bonding is absent in the enzyme's active site, whic...