Sourabh Kosey

Ferroptosis in Neurodegenerative Diseases: Iron Dysregulation, GPX4/FSP1 Signaling, and Emerging Neuroprotective Strategies.

INTRODUCTION Neurodegenerative Diseases (NDDs), including Alzheimer's Disease (AD), Parkinson's Disease (PD), Amyotrophic Lateral Sclerosis (ALS), Huntington's Disease (HD), and Multiple Sclerosis (MS), are increasingly associated with ferroptosis, a regulated irondependent form of cell death characterised by the exces...

NLRP3 Inflammasome Inhibitors as Precision Anti-inflammatory Pharmacotherapy: Translational Advances, Clinical Evidence, and Disease-specific Challenges.

Development and Characterization of β-Cyclodextrin and Methotrexate Inclusion Complex-Based Nanogel for the Management of Rheumatoid Arthritis

A nanoemulsion based gel loaded with the β-CD-MTX inclusion complex provides a hopeful approach to enhance topical MTX delivery, improves therapeutic efficacy, and reduces systemic side effects, thereby addressing important limitations of traditional RA therapy.

Hepatic stellate cells in alcoholic liver cirrhosis: mechanisms of fibrogenesis, plasticity, and fibrosis reversal

Mitochondrial-ferroptotic crosstalk in diabetic Triopathy: a unifying mechanism linking retinal, renal, and neural complications.

This review proposes mitochondrial-ferroptotic crosstalk as a unifying mechanistic axis associating retinal, renal, and neural complications in diabetes, and identifies mitochondrial-ferroptotic crosstalk as a key pathogenic mechanism and therapeutic opportunity to mitigate multi-organ complications in diabetes.

Harnessing the Power of AI: A Modern Review on the Prediction of ADMET Properties in Drug Discovery.

Artificial intelligence-driven ADMET prediction is becoming a vital tool in lowering attrition, speeding up candidate prioritization, and influencing the direction of rational drug development, despite persistent issues with data quality, regulatory acceptance, and synthetic viability.

Pharmacogenomic biomarkers in oncology: evidence, clinical utility, and barriers to implementation.

A critical evaluation of clinically validated PGx biomarkers for chemotherapeutics and targeted therapy with a focus on translational relevance and strength of evidence shows high-impact germline markers such as DPYD, TPMT, NUDT15 and UGT1A1 are highlighted as key determinants of genotype-guided dosing for improving sa...

Neuroinflammation in neurodegenerative diseases: pathogenic pathways and emerging pharmacotherapeutic targets in Alzheimer’s and Parkinson’s disease

New knowledge about the protective and detrimental aspects of neuroinflammation in AD and PD is summarized, providing an analysis on these developing prospects for targeted interventions toward slowing or stopping neurodegeneration.