Open access
Aug 2026
TREM2 drives accumulation of pro-scarring monocyte-derived macrophages in the infarcted myocardium
Myocardial infarction is a leading cause of death and disability worldwide. Ischemic injury leads to irreversible loss of cardiomyocytes, the contractile cells of the heart, and formation of a fibrotic scar. After infarction, macrophages massively infiltrate the heart and orchestrate the tissue repair process by removi...
Giuseppe Rizzo, Marie Piollet, T. Krammer et al.
· bioRxiv · 0 citations