CD40 Signaling Restricts Retrograde Viral Spread and Provides Neuroprotection to Retinal Ganglion Cells in a Murine β-Coronavirus Model of Optic Neuritis
It is demonstrated that CD40 signaling is essential for restricting retrograde axonal transport of the murine β-coronavirus RSA59 from the brain to the retina and for preventing chronic neurodegeneration in a model of viral optic neuritis, revealing a critical link between early immune activation and long-term neuronal...