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Sowmya Dastari

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Open access Aug 2026

Design and Synthesis of Combretastatin A4‐Chalcone Hybrids as Tubulin Polymerization Inhibitors

A new series of combretastatin A4‐chalcone hybrids were designed and synthesized to explore their potential as cytotoxic agents. The compounds were evaluated for cytotoxic activity, tubulin inhibition, and anti‐angiogenic properties. The designed hybrids exhibited significant cytotoxic effects across all the tested can...

Chetna Jadala, S. Telukutla, Ganga Reddy Velma et al. · ChemMedChem · 0 citations