Structural and Ultrastructural Neuropathological Changes in Alzheimer's Disease: Biomarkers, Current Insights and Emerging Perspectives.
Alzheimer's Disease (AD) involves progressive brain changes at both the structural and ultrastructural levels, which begin long before patients present with clinical symptoms. These changes relate to the complex processes of amyloid-β deposition, tau accumulation, synaptic damage, glial activation, impaired vascular fu...