In this study, we present the largest rare coding variant association study of schizophrenia to date, with 87,959 schizophrenia cases and 150,587 controls. We identify 16 genes at exome-wide significance: SETD1A, ZMYM2, HERC1, RB1CC1, SCAF1, XPO7, SP4, FYN, PPP3CA, CUL1, HDAC9, JARID2, ATP9A, PTK2, STAG1, and SCN2A, an...
J. Sealock, C. Dowd, Calwing Liao et al.· bioRxiv· 1 citation
Psoriasis is a heritable, common chronic autoimmune disorder characterized by cycles of remission and flare-ups. Here, we jointly analyze genomic and single-cell transcriptomic data to elucidate the genetic and molecular architecture of psoriasis. We perform a large-scale genome-wide meta-analysis of individuals of Eur...
Hyeonbin Jo, Yeeun Ahn, Beomsu Kim et al.· Nature Communications· 0 citations
A significantly elevated genome-wide rare CNV burden in EAS cases compared with controls is observed, underscoring the importance of increasing population diversity to fully capture the genetic underpinnings of schizophrenia.
Yu Chen, Qi-Di Feng, Max Lam et al.· Nature Genetics· 0 citations
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