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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

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Sravani Malasani

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2 papers indexed here

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Open access Nov 2026

GNG2–MRAS interaction regulates SHOC2-dependent RAF activation and MAPK signaling

Dysregulation of the mitogen-activated protein kinase (MAPK) signaling pathway is a hallmark of many human cancers and RASopathies. The SHOC2–MRAS–PP1Cα (SMP) holophosphatase complex is a crucial regulatory node of this pathway. It activates the MAPK pathway by dephosphorylating the inhibitory phosphoserine on RAF kina...

G. Navale, B. Towolawi, Colin Christoff et al. · 0 citations
Open access Oct 2026

Kinetic signatures of RAS-BRAF engagement reveal isoform selectivity, oncogenic amplification, and mutation-dependent inhibitor resistance.

The RAS-RAF-MEK-ERK (MAPK) signaling cascade is a central regulator of cellular proliferation and differentiation, and its dysregulation is a frequent driver of oncogenesis. RAF activation requires recruitment by GTP-bound RAS at the plasma membrane; however, the precise molecular determinants governing RAS-RAF engagem...

Sravani Malasani, Zhi-Hong Wang · 0 citations

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