RGS6 drives myocyte loss in the diabetic heart via a KLF4/miR-30e/CaMKII-dependent mechanism.
It is demonstrated that high glucose triggers regulator of G protein signaling 6 (RGS6) up-regulation in both human and murine cardiomyocytes, the hearts of hyperglycemic mice, and cardiac tissue samples from individuals with heart failure and a history of diabetes point to RGS6/KLF4 as key sources of pathogenic cardia...