[18F]FPyQCP: A Robust FAP-Targeted PET Tracer Integrating Covalent C−18F Labeling and Radiometal Chelation for Enhanced In Vivo Performance
Fibroblast activation protein (FAP) is a validated PET imaging target for the tumor microenvironment. Currently, most 18F-labeled FAP PET agents use Al−F chemistry, with Al18F-FAPI-74 leading clinically, whereas C−18F tracers perform less effectively. Here, we developed (4-quinolinoyl)glycyl-2-cyanopyrrolidine (QCP)-...