Author

Stefan Simić

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Open access Oct 2026

Rapid HPLC-Based ADME Profiling of Novel Donepezil and Rivastigmine Analogues for Potential Application in Alzheimer’s Disease

Multitarget ligands derived from established cholinesterase inhibitors offer a strategy for addressing the multifactorial pathology of Alzheimer’s disease, but biological potency must be considered together with developability. In this study, a rapid biomimetic high-performance liquid chromatography-based workflow wa...

Stefan Simić, R. Leuci, Marianne Pirker et al. · ACS Omega · 0 citations

Open access Sep 2026

Structural optimization of donepezil-like hybrids toward an improved multi-target and ADME-related profile.

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder involving mainly cholinergic dysfunction, protein misfolding, and metal dyshomeostasis. Considering the complexity of the pathology, multi-target approaches represent a valuable alternative to current approved mono-target treatments. In this study,...

Marco Paparella, R. Leuci, Marco Cerini et al. · Bioorganic chemistry (Print) · 0 citations