Author

Stefano L. Giandomenico

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Open access Oct 2026

Mouse Neural Organoids Model the Mature In Vivo Synaptic Proteome

A protocol to generate mature forebrain organoids from mouse embryonic stem cells is optimized and time-resolved proteomics is used to define the emergence of synaptic proteins during maturation to demonstrate that complex mature synaptic molecular architecture is present within an in vitro organoid environment.

Stefano L. Giandomenico, Marc van Oostrum, Quinn Waselenchuk et al. · bioRxiv · 0 citations

Sep 2026

Mouse Neural Organoids Model the Mature In Vivo Synaptic Proteome

Neural organoids represent a promising approach for modelling neural circuits and neurological disease, yet their utility depends on whether they can recapitulate the molecular complexity of mature brain synapses. Here, we optimized a protocol to generate mature forebrain organoids from mouse embryonic stem cells and u...

Stefano L. Giandomenico, Marc van Oostrum, Quinn Waselenchuk et al. · bioRxiv · 0 citations