Author

Stefano Zineddu

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Open access Sep 2026

Unlocking Iridium Chemical Space for Antibiotic Discovery through One-Pot Combinatorial Synthesis in a Direct-to-Biology Approach

Antibacterial resistance continues to drive the need for exploring novel chemical spaces beyond conventional organic scaffolds. Metal-based compounds have emerged as a promising class of antibiotic candidates, demonstrating high hit rates against priority bacterial pathogens without exhibiting increased toxicity comp...

Çağrı Özsan, A. Welsh, Stefano Zineddu et al. · JACS Au · 0 citations

Open access Jul 2026

Thioredoxin Reductase as a Target for Antibacterial Gold Compounds in Burkholderia cenocepacia: Disclosing the Molecular Basis of Enzyme Inhibition

Thioredoxin reductase from Burkholderia cenocepacia (Bc‐TrxR) is a recognized intracellular target of antibacterial gold(I) compounds, yet the molecular basis of enzyme inhibition remains unclear. Here, we report an integrated structural, biophysical, and biochemical investigation of recombinant Bc‐TrxR and its interac...

Stefano Zineddu, José Aleixo de Azevedo-França, Martina Aguanno et al. · ChemBioChem · 0 citations