Molecular Recognition of Steroids and Bile Salts by Substituted Cyclodextrins: The Influence of Gonane Isomerism and Rim Functionalization on Complexation Thermodynamics
Rim functionalization is what makes cyclodextrins pharmaceutically usable, yet how the type and degree of substitution influence steroid recognition has been established almost solely for conjugated bile salts. Using isothermal titration calorimetry and 1H NMR, we determined the complexation thermodynamics of neutral a...