Author

Stephan Herzig

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Open access Sep 2026

mTORC1-TFEB/TFE3 signaling is associated with bile acid diversification during hepatic metabolic adaptation

The mechanistic target of rapamycin complex 1 (mTORC1) integrates nutrient and hormonal cues to regulate hepatic lipid metabolism with major implications for metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we show that altered hepatic mTORC1–TFEB/TFE3 signaling is associated with coordinated rem...

A. Zaufel, Wenfei Sun, N. Pastore et al. · Science Advances · 0 citations

Open access Sep 2026

Tumor-Secreted ADAMTSL4 Activates Latent TGFβ1 to Drive Cancer Cachexia.

Cancer cachexia is a devastating wasting syndrome with no approved therapies. In this study, we identify the tumor-derived glycoprotein ADAMTSL4 as a circulating factor associated with body weight loss in preclinical cachexia models and patients with colorectal and lung cancers. In mice, Adamtsl4 overexpression convert...

J. Machado, Vignesh Karthikaisamy, Hermine Mohr et al. · Cancer Discovery · 0 citations