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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

Stephen J. Collins

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2 papers indexed here

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Open access Oct 2026

Deciphering the Structure−Activity Relationships Underpinning the Linkerology of Bivalent EGFR Inhibitors

Linking small molecules that bind adjacent sites on a target is a promising strategy for developing compounds with tight binding affinities. ATP-allosteric bivalent inhibitors (AABIs) of the epidermal growth factor receptor (EGFR) have provided new insights into efficient linker design where large potency gains can b...

Kishan B. Patel, I. A. Akinwumi, Tess M. Weber et al. · 0 citations
Open access Sep 2026

Overcoming EGFR Resistance by Monovalent and Bident Inhibitors Targeting Cys775

Covalent targeting of EGFR cysteine 797 by osimertinib is one of the most successful breakthroughs in targeted therapy, fundamentally transforming the treatment landscape for non-small-cell lung cancer (NSCLC) patients. However, resistance driven by the mutation of C797 remains a major clinical challenge. Developing...

Zheng-Nian Li, Jie Jiang, Ya-Ning Wang et al. · 0 citations

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