Stephen M. Farmer

Nervous System Integrity in Drosophila: Essential and Dosage-Sensitive Roles of Hsp110.

The Hsp70 chaperone system is central in maintaining cellular proteostasis. In eukaryotes, its ATP/ADP nucleotide exchange cycle is stimulated by co-chaperone Hsp110, a divergent Hsp70 superfamily member and a modifier of protein misfolding disorders. Hsp110 chaperone functions and pathway interactions have been extens...