Stephen P. Diggle

R-pyocin-mediated selection reverses pan-drug resistance in Pseudomonas aeruginosa

It is demonstrated that R-pyocins can be leveraged not merely as conventional biocides, but as precise selective forces to drive an evolutionary “checkmate” strategy, establishing a framework for using R-pyocins to force predictable evolutionary trade-offs, driving the reversion of multidrug resistance to an attenuated...