ABSTRACT Argentine hemorrhagic fever (AHF) is a disease caused by the Junín virus (JUNV) that can be fatal in 15%–30% of untreated cases. Although JUNV is the only arenavirus for which efficient therapy and vaccination have been established, its administration is limited. In this study, hybridoma technology was used to...
Bacteriophage genomes contain large fractions of uncharacterized genes, motivating high-throughput functional screens to illuminate their roles in host interaction and cytotoxicity. Here, we performed a genome-wide overexpression assay for a Pseudomonas putida KT2440-infecting phage, Emajogi, and identified eight cytot...
Benjamin Diaz, Stephen Won, Meghana Padala et al.· bioRxiv· 0 citations
Overexpression experiments show that Psh protein is secreted by this restored T1SS to confer complete phage resistance, uncover a previously uncharacterized phage defense system in P. putida based on secretion-mediated receptor masking.
Benjamin Diaz, Stephen Won, James D. Jaryenneh et al.· bioRxiv· 0 citations
Existing immunological datasets can support feature-constrained transfer learning for data-efficient prioritization of antibody:antigen interactions across closely related Sarbecoviruses, particularly when conserved epitope regions can be aligned and limited target-specific measurements are available for calibration.
Jimmy B. Yuan, Ryan C. Bruneau, Stephen Won et al.· Frontiers in Immunology· 0 citations
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