SUMMARY Oxidative phosphorylation (OXPHOS) is a key metabolic process that couples redox energy to ATP production. While some core OXPHOS complex subunits are found across all domains of life, many have diverged or expanded across evolution—as seen in the protozoan pathogen Acanthamoeba castellanii. By integrating cryo...
Michelle Y. Fry, Bridget E. Luce, Jonathan A. Stefely et al.· Cell· 4 citations
SUMMARY Giardia lamblia is a microaerophilic protozoan parasite that infects nearly 280 million people worldwide each year. Giardia lacks a mitochondrial genome and mitochondrial enzymes for oxidative phosphorylation. However, it retains mitochondrion-related organelles (MROs) that house an iron-sulfur cluster (ISC) as...
Manish Goyal, Tiana M. Issa, Jonathan A. Stefely et al.· Current Biology· 2 citations
SUMMARY The mitochondrial proteomes of Leishmania tarentolae and Trypanosoma brucei contain ~1,700 proteins, most of which lack homologs in higher eukaryotes. Here, we integrate complexome profiling and cryo-electron microscopy to define conserved and lineage-specific macromolecular assemblies that support mitochondria...
Md Solayman, Yi-Ting Liao, Sarah E. Calvo et al.· Molecules and Cells· 2 citations
A high-throughput assay to quantify stability of thousands of user-defined pHLA produced in E. coli and generated customizable pHLA stability datasets which show how peptide sequence motifs affect pHLA stability, and may be helpful for improving the authors' mechanistic understanding of pHLA stability.
M. Wilbrink, Luis O Correa-Medero, Emma C Duggan et al.· Journal of Immunology· 0 citations
TFiT (tumor-reactive features in T cells), a transcriptional classifier that identifies tumor-reactive T cells and stratifies immunotherapy, but not chemotherapy, response across independent MM and AML cohorts, supporting its specificity for T cell-mediated tumor control.
N. Kehl, T. Wagner, Simon Steiger et al.· Cancer Cell· 1 citation
These results establish motif scaffolding of surface-complementing seeds as an effective strategy for overcoming current limitations of de novo generative models, enabling the design of proteins that can engage challenging interface sites.
D. Britton, Dia A. Ghose, J. Halpin et al.· bioRxiv· 0 citations
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