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Steven D. S. Webbers

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Open access Oct 2026

CRISPR/Cas9-mediated loss of FERMT3 reveals kindlin-3–independent neutrophil activity in LAD-III

Mutations in FERMT3 cause LAD-III by impairing integrin function in neutrophils. Using CRISPR/Cas9, we generated FERMT3 KO cultured neutrophils with normal in vitro granulopoiesis, transcriptomic profiles, and recapitulated defective zymosan-induced ROS production. Basal adhesion and chemotaxis were reduced, whereas st...

Steven D. S. Webbers, Felipe Rojas-Rodriguez, Angela A. F. Gankema et al. · 0 citations

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