Steven F. Baker

Mapping global transcript isoform landscapes of influenza A virus infection and interferon stimulation reveals RNA-binding protein networks associated with immune remodeling

Infected cells rapidly adapt their transcriptional profile to upregulate genes that limit pathogen replication and promote inflammation. Viruses also induce widespread changes in host gene expression, and both host and virus further remodel the transcriptome through targeted mRNA degradation, modulation of alternative...